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Erken doğum ve rahim içi gelişim geriliği ile periodontal hastalık, dişeti oluğu sıvısı ve serum sitokin düzeyleri ve sitokin gen polimorfizmleri arasındaki ilişki

Relations between disease, cytokine levels in gingival crevicular fluid and serum, cytokine gene polymorphisms, preterm birth and the intra-uterine growth restriction in postpartum women

  1. Tez No: 163713
  2. Yazar: NEZAHAT ARZU ÇAĞLI
  3. Danışmanlar: DOÇ.DR. NİLGÜN ÖZLEM ALPTEKİN
  4. Tez Türü: Doktora
  5. Konular: Diş Hekimliği, Dentistry
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2005
  8. Dil: Türkçe
  9. Üniversite: Selçuk Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Periodontoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 133

Özet

7. SUMMARY Relations Between Periodontal Disease, Cytokine Levels in Gingival Crevicular Fluid and Serum, Cytokine Gene Polymorphisms, Preterm Birth and the Intra-Uterine Growth Restriction in Postpartum Women The aim of this study was to evaluate the relations between periodontal disease, cytokine levels in gingival crevicular fluid (gcf) and serum (sr); cytokine gene polymorphisms; preterm birth (PB) and intra-uterine growth restriction (IUGR) in postpartum woman. Out of 156 subjects, 64 subjects with normal birth (NB), 45 subjects with PB and 47 subjects with IUGR ranging in age from 18 to 34 years were included in this study. The features related with their pregnancy period, demographic characteristics and clinical periodontal parameters of this population were evaluated. Levels of interleukin (IL)-ip and IL-lra were analized with ELISA and EIA methods. Polymorphisms of IL-1A (IL-lcc+4845), IL-1B (IL-ip+3954) and IL-1RN (IL-lra) genes were determined with polimerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. The mean value of the age in IUGR group was higher than in NB and PB groups (PO.05). The number of subject who did not pay regular prenatal visits and who had previous delivery with low birth weight in NB group was lower than in the other groups (PO.05). The ratio of subjects with healthy periodontal tissues and the ones who recieved antibiotics during pregnancy in NB group were higher than than in other groups (PO.05). The mean values of probing depth (PD) and clinical attachment loss (CAL) in PB and IUGR groups were higher than in NB group, but IL-ipgcf and IL-lra gcf levels in this groups were lower than in NB group (PO.05). While IL-lpsr levels could not be measured in any samples, IL-lrasr concentrations were similar in each three groups (P>0.05). As regards to the genotype frequencies of IL-1A 95and IL-1B, no differences were found between NB, PB and IUGR groups (P>0.05). In this study, we found that IL-1RN“allel”2+ property was closely related with ED and IUGR (PO.05). There was no relation between IL-1A, IL-1B, IL-RN polymorphisms and periodontal disease. Within the limits of this study, we concluded that the most significant risk factors associated with PB and IUGR were IL-1RN“allel”2+ property and periodontal disease characterized with CAL. 96

Özet (Çeviri)

7. SUMMARY Relations Between Periodontal Disease, Cytokine Levels in Gingival Crevicular Fluid and Serum, Cytokine Gene Polymorphisms, Preterm Birth and the Intra-Uterine Growth Restriction in Postpartum Women The aim of this study was to evaluate the relations between periodontal disease, cytokine levels in gingival crevicular fluid (gcf) and serum (sr); cytokine gene polymorphisms; preterm birth (PB) and intra-uterine growth restriction (IUGR) in postpartum woman. Out of 156 subjects, 64 subjects with normal birth (NB), 45 subjects with PB and 47 subjects with IUGR ranging in age from 18 to 34 years were included in this study. The features related with their pregnancy period, demographic characteristics and clinical periodontal parameters of this population were evaluated. Levels of interleukin (IL)-ip and IL-lra were analized with ELISA and EIA methods. Polymorphisms of IL-1A (IL-lcc+4845), IL-1B (IL-ip+3954) and IL-1RN (IL-lra) genes were determined with polimerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. The mean value of the age in IUGR group was higher than in NB and PB groups (PO.05). The number of subject who did not pay regular prenatal visits and who had previous delivery with low birth weight in NB group was lower than in the other groups (PO.05). The ratio of subjects with healthy periodontal tissues and the ones who recieved antibiotics during pregnancy in NB group were higher than than in other groups (PO.05). The mean values of probing depth (PD) and clinical attachment loss (CAL) in PB and IUGR groups were higher than in NB group, but IL-ipgcf and IL-lra gcf levels in this groups were lower than in NB group (PO.05). While IL-lpsr levels could not be measured in any samples, IL-lrasr concentrations were similar in each three groups (P>0.05). As regards to the genotype frequencies of IL-1A 95and IL-1B, no differences were found between NB, PB and IUGR groups (P>0.05). In this study, we found that IL-1RN“allel”2+ property was closely related with ED and IUGR (PO.05). There was no relation between IL-1A, IL-1B, IL-RN polymorphisms and periodontal disease. Within the limits of this study, we concluded that the most significant risk factors associated with PB and IUGR were IL-1RN“allel”2+ property and periodontal disease characterized with CAL. 96

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