Tip 1 ve tip 2 diyabetli hastaların diyabet tutumunun değerlendirilmesi
Evaluation of the attitudes of type 1 and type 2 diabetic patients
- Tez No: 193403
- Danışmanlar: PROF.DR. ZEHRA DURNA
- Tez Türü: Yüksek Lisans
- Konular: Hemşirelik, Nursing
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2006
- Dil: Türkçe
- Üniversite: İstanbul Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: İç Hastalıkları Hemşireliği Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 119
Özet
XVABSTRACTTunçdemir M. The effects of ACE inhibitor and angiotensin receptor blocker onclusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. İstanbulUniversity, Institute of Health Science, Medical Biology Dept. Ph.D.Thesis. Istanbul2006.The aim of this study was to determine the roles of secreted clusterin (s-clu) and nuclearclsuterin (n-clu) expressions in experimental diabetic nephropathy, and to investigatethe effects on clusterins expression after treatment angiotensin II blockade and comparethese results with apoptosis. Five groups, each containing 8 male Wistar albino ratswere included in this study. Four groups received streptozotocin injection (STZ, 60mg/kg, single dose, ip). On the 2nd day of STZ injection the rats developing diabeteswere divided into 4 groups. First group was STZ-diabetic. Second group was irbesartantreated diabetics (15 mg/kg/day, gavage, 30 days). Third group was perindopril treateddiabetics (6 mg/kg/day, gavage, 30 days), Fourth group was combined treated diabeticgroup with perindopril and irbesartan (respectively, 3 mg/kg/day, 5 mg/kg/day, gavage,30 days). Fifth group was the healthy control. During the experimental period bloodglucose, microalbuminuria levels, body weights, kidney weight and amount of dailyurine were measured. At the end of experiment, renal tissue samples were fixed informaline and embedded in paraffin. PAS staining and TUNEL method andimmunohistochemical staining for TGF-β1, α-SMA, clusterin-β (for s-clu) andclusterin-α/β (for n-clu) antigenes were performed for histological examinations. Bloodglucose levels and body weight/kidney weight values of all STZ-diabetic groups werehigher than the healthy control group. The level of daily urine and microalbuminurialevels were decreased in the all treated diabetic groups (p
Özet (Çeviri)
XVABSTRACTTunçdemir M. The effects of ACE inhibitor and angiotensin receptor blocker onclusterin and apoptosis in the kidney tissue of streptozotocin-diabetic rats. İstanbulUniversity, Institute of Health Science, Medical Biology Dept. Ph.D.Thesis. Istanbul2006.The aim of this study was to determine the roles of secreted clusterin (s-clu) and nuclearclsuterin (n-clu) expressions in experimental diabetic nephropathy, and to investigatethe effects on clusterins expression after treatment angiotensin II blockade and comparethese results with apoptosis. Five groups, each containing 8 male Wistar albino ratswere included in this study. Four groups received streptozotocin injection (STZ, 60mg/kg, single dose, ip). On the 2nd day of STZ injection the rats developing diabeteswere divided into 4 groups. First group was STZ-diabetic. Second group was irbesartantreated diabetics (15 mg/kg/day, gavage, 30 days). Third group was perindopril treateddiabetics (6 mg/kg/day, gavage, 30 days), Fourth group was combined treated diabeticgroup with perindopril and irbesartan (respectively, 3 mg/kg/day, 5 mg/kg/day, gavage,30 days). Fifth group was the healthy control. During the experimental period bloodglucose, microalbuminuria levels, body weights, kidney weight and amount of dailyurine were measured. At the end of experiment, renal tissue samples were fixed informaline and embedded in paraffin. PAS staining and TUNEL method andimmunohistochemical staining for TGF-β1, α-SMA, clusterin-β (for s-clu) andclusterin-α/β (for n-clu) antigenes were performed for histological examinations. Bloodglucose levels and body weight/kidney weight values of all STZ-diabetic groups werehigher than the healthy control group. The level of daily urine and microalbuminurialevels were decreased in the all treated diabetic groups (p
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