Geri Dön

Koroziv özofagus yanıklarında resveratrolün inflamasyon ve striktür oluşumu üzerine etkilerinin deneysel olarak araştırılması

The antiinflamatory and antifibrotic effect of resveratrol in experimental caustic esophageal burn

  1. Tez No: 195713
  2. Yazar: CESİM İRŞİ
  3. Danışmanlar: DOÇ. DR. SEMA UĞURALP
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Çocuk Cerrahisi, Pediatric Surgery
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2007
  8. Dil: Türkçe
  9. Üniversite: İnönü Üniversitesi
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: Çocuk Cerrahisi Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 58

Özet

The purpose of medical treatment in the caustic esophageal burns (CEB) is to decrease inflammatory reaction and to prevent stricture formation. Resveratrol have got antiinfiammatory and antifibrotic properties. The aim of the study was investigated the effects of resveratrol antiinfiammatory and suppressing stricture formation in experimental CEB.Fourty-two male Wistar albino rats were divided into five groups as follows Control group, caustic group 4 and 28 group (esophageal burns were created), resveratrol 4 and 28 group (esophageal burns were created and resveratrol were given). CEB were produced by the method of Gehanno and Guedon as modified by Liu and Richardson, 25 % NaOH were used for burns. Animals were sacrificed on the 4th and 28th days for biochemical and histopathologic examination. Mean malondialdehyde and nitric oxide assays of the caustic groups were significantly higher than in the resveratrol groups (p

Özet (Çeviri)

The purpose of medical treatment in the caustic esophageal burns (CEB) is to decrease inflammatory reaction and to prevent stricture formation. Resveratrol have got antiinfiammatory and antifibrotic properties. The aim of the study was investigated the effects of resveratrol antiinfiammatory and suppressing stricture formation in experimental CEB.Fourty-two male Wistar albino rats were divided into five groups as follows Control group, caustic group 4 and 28 group (esophageal burns were created), resveratrol 4 and 28 group (esophageal burns were created and resveratrol were given). CEB were produced by the method of Gehanno and Guedon as modified by Liu and Richardson, 25 % NaOH were used for burns. Animals were sacrificed on the 4th and 28th days for biochemical and histopathologic examination. Mean malondialdehyde and nitric oxide assays of the caustic groups were significantly higher than in the resveratrol groups (p

Benzer Tezler

  1. Deneysel özofagus yanığı modelinde l glutamin,intralezyoner ve sistematik kortikosteroid uygulamalarının darlık gelişimine etkilerinin karşılaştırılmalı olarak incelenmesi

    Comparative investigation of the effects of l glutamine, intralesionary and systematic corticosteroid applications on the development of stricture in experimental esophagus burns model

    ÖZKAN OKUR

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2012

    Çocuk CerrahisiSağlık Bakanlığı

    Çocuk Cerrahisi Ana Bilim Dalı

    PROF. DR. MÜNEVVER HOŞGÖR

  2. Koroziv özofagus yanıklarında özofagoskopi sonrası yapılan usg, ömd ve 24 saat ph monitorizasyonu sonuçlarının karşılaştırılması

    Comparison of usg, omd and 24-hour ph monitoring results after esophagoscopy in corrosive esophageal burns

    HASAN DEMİRKAN

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2013

    Çocuk CerrahisiSağlık Bilimleri Üniversitesi

    Çocuk Cerrahisi Ana Bilim Dalı

    DOÇ. DR. HÜSEYİN TUĞRUL TİRYAKİ

  3. Koroziv özofagus yanıklarında ailelerin eğitim gereksinimlerinin kart sort tekniği ile belirlenmesi

    Determination of education needs of families via card sort technique in corrosive esophagus burns

    NURDAN AKÇAY

    Yüksek Lisans

    Türkçe

    Türkçe

    2006

    Eğitim ve ÖğretimEge Üniversitesi

    Çocuk Cerrahisi Ana Bilim Dalı

    PROF. DR. ZEYNEP CONK

  4. Koroziv özofagus yanıklarında 'dımethyl sulfoxıde- (dmso)' in histopatolojik bulgular üzerine etkisi

    The effects of dmso on histopathological findings in corrosive esophageal burns

    HÜSEYİN KILINÇASLAN

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2005

    Biyolojiİstanbul Üniversitesi

    Çocuk Cerrahisi Ana Bilim Dalı

    PROF.DR. HÜSEYİN ÖZBEY