Fare atriyumunda bazı agonistlerin etkileri
Başlık çevirisi mevcut değil.
- Tez No: 22369
- Danışmanlar: DOÇ. DR. NURETTİN ABACIOĞLU
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1992
- Dil: Türkçe
- Üniversite: Gazi Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Farmakoloji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 100
Özet
ÖZET 1-Bu çalınmada spontan alımlı izole fare atriyumunda HA (3xlO~7- 10-*M) ve 4-metilhistaminin
Özet (Çeviri)
.u Hilal fl(XtrM*-m*(ıL- uınalucloy Anabil üaU ? ^'2_ SUMMARY 1- Ih ThTs sTTüdy, tB^7“roXe”“öt''”vaT“tıra5'_Hi”“anı^”“”if«“”“”~«tıtTtgtnr-i-st xm histamine (3xİ0-T-10-° M) 4-methylhistamine (3xi0-*-10-« M) induced positive chronotropic effect has been investigated in spontaneously beating right atria of mice. 2- Histamine and 4-methylhistamine caused a concentration related increase in the rate of isolated right atria of mice. 3- Me py ramine (10~s, 10~a, 10~TM) as Ha. receptor blocker, famotidin (10-*, 10~T, 10-*M), cimetidine (10~s, 10-T, 10-“8M) and lupitidin (SKF 93579) (10”*, 10~a, 1Q-«M) as Ha receptor blockers and ikotidin (10_a, 10-T, 10_SM) as a nonspecific Hi and Ha receptor blockers were used to assess affinity constants for their respective receptors. 4- Beside the specific histamine receptor blockers, a 0-blocker propranolol (10~s, 10_T, 10~eM) was used for indicating whether noradrenaline release occured in this tissue or not. 5- An uptake i blocker cocaine (10~TM) also used to reverse an amine uptake. 6- For estimating of the apparent pAB values, Schild regression was used as an indicator of simple competitive inhibition. 7- Since the slope and linearity of a Schild regression are sensitive indicators of non-equilibrium conditions in an isolated tissue, in the present study, deviations of the slopes from unity evaluated from the Schild regressions were used as a tool to define the possible mechanisms which were involved in HA- induced responses.8- Results were indicated that isolated right atrium of mice has heterogenous histamine receptor distribution (Hi and He receptors). Both receptors were mediated by HA- induced chronotropic effect with an involvement of noradrenaline release which was potentiated, the chronotropy. It has also been found that, there was a significant amine uptake in this t i s s ue.
Benzer Tezler
- Spesifik proton pompası inhibitörlerinin düz kas, çizgili kas ve kalp kasının mekanik ve elektriksel özellikleri üzerine etkileri
The effects of specific proton pump inhibitors on the contractile and electrophysiological properties of smooth, striated and cardiac muscles
AYDAN YENİŞEHİRLİ
Doktora
Türkçe
2001
Eczacılık ve FarmakolojiHacettepe ÜniversitesiFarmakoloji Ana Bilim Dalı
PROF. DR. RÜŞTÜ ONUR
DOÇ. DR. ALPER BEKTAŞ İSKİT
- Fare lenfoid organlardaki özel venüllerin (HEV'lerin) ince yapılarının, glikozaminoglikanlarının ve lenfosit göçünün karşılaştırılması
The Comparison of ultrastructures, glycosaminoglycans and lymphocyte migration of specialized venules (HEVs) of the mouse lymphoid tissues
ERDAL BALCAN
- Fare trakeasının çeşitli ajanlara yanıtlarında dokunun elde edilme zamanının önemi var mı?
Is time of the obtaining tissue important in the responsiveness of mice trachea to various agents?
METE TAN
Doktora
Türkçe
1998
Eczacılık ve FarmakolojiGazi ÜniversitesiFarmakoloji Ana Bilim Dalı
PROF. DR. HAKAN ZENGİL
- Fare göz ön kamarasına Plasmodium Berghei kan evresi antijenleri uygulamasının parazitemi, serum TNF alfa, IL-6 ve nitrik oksit düzeylerinde oluşturduğu değişiklikler
Changes in parasitemia, serum TNF alpha, IL-6 levels caused by the treatment of blood stage Plasmodium Berghei antigens into mouse anterior chamber of the eye
İSHAK ÖZEL TEKİN
- Fare embriyolarının in vitro kültüründe farklı BSA oranlarının gelişime etkisi
Effect of various BSA levels on development of mouse embryos in vitro culture
MİTHAT EVECEN
Doktora
Türkçe
1999
Veteriner Hekimliğiİstanbul ÜniversitesiDölerme ve Suni Tohumlama Ana Bilim Dalı
PROF. DR. İ. KAMURAN İLERİ