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İnsüline bağımlı olmayan diabetik hastalarda serum siyalik asit düzeyinin kan basıncı ve retinopatiyle ilişkisi

Serum sialic acid concentrations in patients with non-insulin dependet diabetes mellitus and it's relationship to blood pressure and retinopathy

  1. Tez No: 38167
  2. Yazar: AHMET ERDİL
  3. Danışmanlar: PROF.DR. FİKRİ KOCABALKAN
  4. Tez Türü: Tıpta Uzmanlık
  5. Konular: Endokrinoloji ve Metabolizma Hastalıkları, Endocrinology and Metabolic Diseases
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1994
  8. Dil: Türkçe
  9. Üniversite: GATA
  10. Enstitü: Tıp Fakültesi
  11. Ana Bilim Dalı: İç Hastalıkları Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 46

Özet

SUMMARY Serum Sialic Acid Concentrations in Patients with Non-Insulin Dependent Diabetes Mellitus and It's Relationship to Blood Pressure and Retinopathy. In the formation of diabetic retinopathy that is an important complication of diabetes mellitus, it is supposed that together with high blood glucose the increasing sialic acid in diabetes mellitus plays an important role. In this study, we investigated serum total sialic acid levels relate to glysemic control, blood pressure, retinopathy and serum lipid levels in diabetic patients. We selected 62 patients with type II diabetes mellitus as a research group and after fundoscopic examinations they were classified in two groups. 31 patients did not have any retinopathy and any other complications, in the other group 20 patients had background retinopathy, 1 1 patients had background retinopathy and maculopathy. 35 of the studied patients were female, 27 of them were male, having ages ranging from 41 to 74. While 23 patients had less than 5 years of diabetic duration, 39 of them had 5 or over 5 years. We selected 31 normal (healthy) subjects at random and matched them for age and sex with patients. Serum total sialic acid levels in the patients were found significantly higher than normal subjects (p0.05). There was no significant relationship of total sialic acid with another parameters in normal subjects (p>0.05). 38As a conclusion, according to this study total serum sialic acid levels are very important in diabetic patients. Gradually increasing silica acid levels in diabetic patients by destroying to the cell structure plays and important role in retinopathy formations. There is a relationship of sialic acid with high blood pressure that has an influence in retinopathy formation. It is possible to prevent excessive increasing of serum sialic acid levels by a good diabetic regulation and keeping blood pressures in normal ranges, thus retinopathy formations can be decreased. To determine the relationship of the sialic acid to warriors' parameters, should be made more studies in larger groups of diabetic patients including insulin dependent diabetic subjects. 39

Özet (Çeviri)

SUMMARY Serum Sialic Acid Concentrations in Patients with Non-Insulin Dependent Diabetes Mellitus and It's Relationship to Blood Pressure and Retinopathy. In the formation of diabetic retinopathy that is an important complication of diabetes mellitus, it is supposed that together with high blood glucose the increasing sialic acid in diabetes mellitus plays an important role. In this study, we investigated serum total sialic acid levels relate to glysemic control, blood pressure, retinopathy and serum lipid levels in diabetic patients. We selected 62 patients with type II diabetes mellitus as a research group and after fundoscopic examinations they were classified in two groups. 31 patients did not have any retinopathy and any other complications, in the other group 20 patients had background retinopathy, 1 1 patients had background retinopathy and maculopathy. 35 of the studied patients were female, 27 of them were male, having ages ranging from 41 to 74. While 23 patients had less than 5 years of diabetic duration, 39 of them had 5 or over 5 years. We selected 31 normal (healthy) subjects at random and matched them for age and sex with patients. Serum total sialic acid levels in the patients were found significantly higher than normal subjects (p0.05). There was no significant relationship of total sialic acid with another parameters in normal subjects (p>0.05). 38As a conclusion, according to this study total serum sialic acid levels are very important in diabetic patients. Gradually increasing silica acid levels in diabetic patients by destroying to the cell structure plays and important role in retinopathy formations. There is a relationship of sialic acid with high blood pressure that has an influence in retinopathy formation. It is possible to prevent excessive increasing of serum sialic acid levels by a good diabetic regulation and keeping blood pressures in normal ranges, thus retinopathy formations can be decreased. To determine the relationship of the sialic acid to warriors' parameters, should be made more studies in larger groups of diabetic patients including insulin dependent diabetic subjects. 39

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