Development of magnetic resonance based spin labeling techniques for functional brain imaging
Başlık çevirisi mevcut değil.
- Tez No: 508414
- Danışmanlar: Prof. KâMİL ULUDAĞ, Prof. FRITZ SCHICK
- Tez Türü: Doktora
- Konular: Nöroloji, Nöroşirürji, Radyoloji ve Nükleer Tıp, Neurology, Neurosurgery, Radiology and Nuclear Medicine
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2012
- Dil: İngilizce
- Üniversite: Eberhard-Karls-Universität Tübingen
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 155
Özet
Özet yok.
Özet (Çeviri)
Since its invention in 1992, arterial spin labeling (ASL) has become a widely used tool for noninvasively investigating brain function. Because ASL provides a direct and repeatable measurement of CBF, these methods are highly applicable in studies of cognitive neuroscience, in the evaluation of pharmacological treatments and in the diagnosis of CBF related diseases. The focus of this dissertation is on the development and implementation of arterial spin labeling techniques ultimately with applications in neuroscience. On the technical side, the systematic errors in ASL experiments such as transit delay time artifacts are investigated for various ASL methods including pulsed, pseudo-continuous and dual coil continuous sequences. Magnetization dispersion effects on quantitative CBF estimation are explored and the regional bias that occurs as a result of varying transit delay times is characterized. Different pulsed ASL encoding schemes are compared from the aspects of their relative signal-to noise ratio (SNR) and absolute CBF estimates. A new method is proposed to calculate the equilibrium magnetization of arterial blood which is required for absolute CBF quantification and compared with those other methods. Taking the advantage of better spatial localization and sensitivity profile of ASL compared to blood oxygenated level dependent (BOLD) signal, retinotopic mapping of human brain with perfusion contrast is performed and variations of hemodynamic delay times across the visual areas in BOLD and perfusion activations are investigated. Further on the application side, a number of neuroscience projects performed in collaboration are presented: i) The covariation of local anatomical connectivity, gray matter volume and perfusion is quantified by conducting an integrative MRI study utilizing a combination of diffusion tensor imaging, arterial spin labeling and anatomical imaging ii) Differential effects of intranasal insulin and caffeine on cerebral blood flow is investigated iii) the spatial sensitivities of widely used fMRI sequences such as gradient echo-BOLD, spin echo-BOLD and arterial spin labeling are compared with respect to optimal transcranial magnetic stimulation (TMS) sites for evoking highest motor responses. Overall, the results presented in this thesis are addressing the questions related to the technical and methodological problems in arterial spin labeling and its applications in functional brain imaging.
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