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Aspiration-assisted bioprinting

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  1. Tez No: 719866
  2. Yazar: BUĞRA AYAN
  3. Danışmanlar: PROF. DR. İBRAHİM TARIK ÖZBOLAT
  4. Tez Türü: Doktora
  5. Konular: Makine Mühendisliği, Mühendislik Bilimleri, Mechanical Engineering, Engineering Sciences
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2022
  8. Dil: İngilizce
  9. Üniversite: The Pennsylvania State University
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 160

Özet

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Özet (Çeviri)

Each year there are approximately 130,000 organ transplants conducted worldwide. Although a substantial number of organ transplantation, the current situation is far away from meeting the demand so that many people on the waitlist die each day. The supply of transplantable tissue faces the same complications and relies on a series of grafting techniques. Allografts (tissue from another human) and xenografts (tissue from an animal) are used to increase supply but these methods have a variety of issues. These problems include the possibility of rejection due to the presence of specific histocompatibility antigens that are targeted by antibodies in the recipient, and for the later there is a risk of microbial or viral transmission resulting in novel diseases. Autografts (tissue from the patient) eliminate the concerns of the previous two methods thanks to the use of genetically identical tissues. However, Autografts are only applicable in a small number of cases due to a lack of supply and large cost associated with the procedure. There is a clear need for cheap, accessible, and biocompatible tissues and organs for transplantation with a possible solution lying in bioprinting. Bioprinting offers a promising technology to fuse the high precision and time efficient qualities of additive manufacturing with tissue engineering to replicate morphogenesis with the ultimate goal of producing artificial tissues and organs on an industrial scale. This dissertation has centered on understanding, designing, and prototyping a new hybrid bioprinting process, called“Aspiration-assisted Bioprinting (AAB),”which enables to pick and precisely bioprint a wide of range of biologics, with dimensions in an order-of-magnitude range (80-800 μm), into/onto a gel substrate with minimal cellular damage. In order to better understand the response of biologics to the bioprinting process, the underlying mechanism explaining the physical behavior of viscoelastic spheroids and their interactions with physical governing forces during aspiration, lifting and bioprinting were unveiled. Compared to existed methods, the approach that was explored in this dissertation facilitated the bioprinting of spheroids in higher iv positional precision and accuracy, ~11 and ~15% with respect to the spheroid size, respectively. In addition, it enabled bioprinting in 3D with flexibility of bioprinting of non-uniform, any-size spheroids into (I) a functional gel as a scaffold-based approach or (II) a sacrificial gel as a scaffoldfree approach. The newly-developed AAB platform, modified from a Makerbot Replicator I (

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