Geri Dön

Sympathetic neural control of inflammation by ADRB2-mediatedIl-10 secretion

Başlık çevirisi mevcut değil.

  1. Tez No: 765276
  2. Yazar: DIDEM AĞAÇ
  3. Danışmanlar: PROF. DR. J. DAVİD FARRAR
  4. Tez Türü: Doktora
  5. Konular: Biyomühendislik, Bioengineering
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2018
  8. Dil: İngilizce
  9. Üniversite: The University of Texas Southwestern Medical Center at Dallas
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Biyomedikal Bilimler ve Mühendislik Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 211

Özet

Özet yok.

Özet (Çeviri)

The nervous and immune systems reciprocally regulate their functions through the release of chemical messengers. Norepinephrine (NE), a neurotransmitter released by catecholaminergic nerve endings, allows the sympathetic nervous system to communicate with immune cells through adrenergic receptors (ADR). Although, the effects of adrenergic signaling has been studied in multiple cell types, its role in modulation of innate immune cells is relatively unknown. Here, I demonstrate a novel role for the b2-ADR (ADRB2) in controlling inflammation. NE suppresses pro-inflammatory cytokine secretion from primary macrophages in response to multiple TLR agonists, and ADRB2 signaling enhances early induction of IL-10. In addition to its in vitro affects, I have shown that ADRB2 signaling controls inflammation in vivo. The in vivo role of this pathway was assessed by using aninfection model, experimental colitis and LPS endotoxemia model. ADRB2-/- animals presented with splenomegaly and greater weight loss in infection and colitis, compared to ADRB2 sufficient animals, respectively. ADRB2-/- animals rapidly succumbed to a sublethal LPS challenge, which correlated with elevated serum levels of TNFα and reduced IL10. Administration of exogenous IL-10 increased the survival of the ADRB2-/- . Additionally, the ADRB2-specific agonist salmeterol rescued wild-type animals from a lethal LPS challenge, which was reversed by neutralizing anti-IL-10 antibody. These observations suggest that ADRB2 signaling is critical for controlling inflammation through the rapid induction of IL-10. Transcriptome analysis revealed that the NR4A nuclear orphan family members were induced by NE. The presence of several putative NR4A binding sites within the IL-10 promoter suggests that these factors may directly regulate IL-10 expression in response to ADRB2 signaling. Additionally, mice that deficient in NR4A1 are susceptible in LPS endotoxemia model. These results suggest a novel pathway for control of inflammation via neuroendocrine cues. Understanding this pathway will provide new insights into how the nervous and immune systems communicate through ADRB2 signaling

Benzer Tezler

  1. Klasik çift odacıklı kalıcı kalp pili takılan hastalarda, değişik atriyoventriküler ileti zamanlarının karotis-femoral (aortik) nabız dalga hızı ölçümü ile belirlenen arter genişleyebilirliği ve serum norepinefrin düzeylerine etkisi

    The effect of differential atrioventricular delays on arterial distensibility measured by carotid-femoral (aortic) pulse wave velocity and serum norepinephrine levels in patients with ddd pacing

    BETÜL BALABAN KOÇAŞ

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2015

    Kardiyolojiİstanbul Üniversitesi

    Kardiyoloji Ana Bilim Dalı

    PROF. DR. MUSTAFA YILDIZ

  2. Kalp-damar hastalarında a tipi davranış ve öfke analizi

    Analysis of A type behavior pattern and anger profiles in patients with coronary heart disease

    ALİ GÜHER ENİSELER

    Yüksek Lisans

    Türkçe

    Türkçe

    2007

    BiyolojiCelal Bayar Üniversitesi

    Biyoloji Ana Bilim Dalı

    Y.DOÇ.DR. SELİM UZUNOĞLU

  3. El ve ense sempatik deri yanıtları ile kan basıncı arasındaki ilişkinin araştırılması

    Investigation of the relationship between hand and neck sympathetic skin responses with blood pressure

    MERVE ÖNERLİ

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2020

    NörolojiBolu Abant İzzet Baysal Üniversitesi

    Nöroloji Ana Bilim Dalı

    PROF. DR. SERPİL YILDIZ

  4. Tip 2 diyabetik hastalarda neudesin düzeyi ve metabolik parametrelerle ilişkisi

    In type 2 diabetic patiens neudesin levels and relationship between metabolic parameters

    ÖVGÜ KARATAŞ

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2018

    Endokrinoloji ve Metabolizma HastalıklarıSağlık Bilimleri Üniversitesi

    İç Hastalıkları Ana Bilim Dalı

    DOÇ. DR. ARİF YÜKSEL

  5. Endometrioziste neurotrimin nöronal adezyon molekülünün ekspresyonunun araştırılması

    A neuronal adhesion molecule neurotrimin expression in endometriosis

    DERYA ECE ILIMAN

    Tıpta Uzmanlık

    Türkçe

    Türkçe

    2022

    Kadın Hastalıkları ve DoğumSağlık Bilimleri Üniversitesi

    Kadın Hastalıkları ve Doğum Ana Bilim Dalı

    PROF. DR. MURAT EKİN