In vitro - in vivo evaluation of carbamazepine conventional tablets
Karbamazepin konvansiyonel tabletlerinin in vitro in vivo incelenmesi
- Tez No: 102773
- Danışmanlar: PROF.DR. NURŞEN ÜNLÜ, PROF.DR. YILMAZ ÇAPAN
- Tez Türü: Yüksek Lisans
- Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
- Anahtar Kelimeler: Carbamazepine, polymorphism, dissolution rate, bioavailability
- Yıl: 2001
- Dil: İngilizce
- Üniversite: Hacettepe Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Farmasötik Teknoloji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 15107
Özet
Özet yok.
Özet (Çeviri)
V ABSTRACT Elqidra, R., In Vitro-In Vivo Evaluation of Carbamazepine Conventional Tablet, Hacettepe University, Institute of Health Sciences, Thesis on Master of Degree in Pharmaceutical Technology, Ankara - Turkey, 2001. Carbamazepine (CBZ) is a widely used antiepileptic agent because of its favorable therapeutic profile. Following the oral administration, gastrointestinal absorption of CBZ is an irregular process and changes as a result of dissolution variations. CBZ is a compound which exhibits polymorphism and pseudopolymorphism. Variation in gastrointestinal absorption of CBZ is atributed the different crystalline forms of the drug in dosage forms. In the present study, four different polymorps of CBZ (a,J3,y, dihydrate) were obtained and the conventional tablets containing these crystalline forms were prepared. The effect of polymorphism on the dissolution and bioavailability of CBZ was investigated by the in vitro dissolution test and the in vivo bioavailability study. The tablets were investigated by in vitro dissolution test according to pharmacopeial recommendations. Tegretol, was selected a brand name product of CBZ to compare the in vitro - in vivo behaviour of the formulations. 3 form tablets which demonstrated the lowest dissolution rate while a and amorphous CBZ exhibited the highest dissolution rates similarly. Dissolution rates were affected significantly by different crystalline forms of CBZ. Tegretol®, amorhous bulk CBZ and |3 CBZ tablets were selected for in vivo bioavailability study. Six healthy volunteers were participated in a open- randomized cross-over designed clinical trial. After 96 h as a total blood sampling period, plasma levels of CBZ were determined by HPLC method using CN column and an acetonitrile-water (30:70) mobile phase. Pharmacokinetic parameters including the area ubder the curves (AUc o-*»), plasma peak concentrations (Cnwx) and peak times (W) were calculated. Absorption profiles of three tablets tested clinically appeared to be in accordance with their dissolution profiles. But no significant difference between (AUc a-»») and (Cmu) values was found. Only (tmax) values demonstrated a significant difference from each other.
Benzer Tezler
- Karbamazepin içeren kontrollü salım sağlayan (oral ve biyoadheziv) tabletlerin formülasyonu ve in vitro/in vivo değerlendirilmesi
Formulation and in vitro/in vivo evaluation of contrelled release carbomozepine (oral and bioadhesive) tablets
GÜLCAN İKİNCİ
Yüksek Lisans
Türkçe
1997
Eczacılık ve FarmakolojiHacettepe ÜniversitesiFarmasötik Teknoloji Ana Bilim Dalı
PROF. DR. YILMAZ ÇAPAN
- Deneysel rat trigeminal nevralji modelinde nanopartiküle bağlanmış karbamazepinin intranazal yolla uygulanmasının davranışsal etkilerinin incelenmesi
Investigation of the behavioral effects of intranasal administration of nanoparticle-bound carbamazepine in an experimental rat model of trigeminal neuralgia
CAN EKER
Tıpta Uzmanlık
Türkçe
2024
BiyomühendislikHacettepe ÜniversitesiBeyin ve Sinir Cerrahisi Ana Bilim Dalı
PROF. DR. HALİL KAMİL ÖGE
- İmmünokemoterapötik nanoplekslerin kolon kanseri tedavisinde etkinlik ve güvenliğinin in vitro - in vivo değerlendirilmesi
İn vitro- in vivo evaluation of immunochemotherapeutic nanoplexes effi̇cacy and safety for the treatment of colon cancers
SAFİYE AKKIN
Doktora
Türkçe
2022
Eczacılık ve FarmakolojiHacettepe ÜniversitesiFarmasötik Teknoloji Ana Bilim Dalı
PROF. DR. EREM BİLENSOY
- Mikroküre partikül büyüklüğünün hedeflendirmedeki rolünün in vitro - in vivo değerlendirilmesi
In vitro - in vivo evaluation of the role of microsphere particle size on the targeting
YALÇIN ÖZKAN
- İnflamatuvar bağırsak hastalığı modelinde nanopartiküler sistemlerin in vitro/in vivo değerlendirilmesi
In vitro/in vivo evaluation of nanoparticular systems in inflammatory bowel disease model
SERKAN YENER
Yüksek Lisans
Türkçe
2013
Eczacılık ve FarmakolojiGazi ÜniversitesiFarmasötik Teknoloji Ana Bilim Dalı
PROF. DR. FÜSUN ACARTÜRK