Farelerde pentilentetrazol ile geliştirilen epilepsiye endokannabinoidlerin etkisi
Effects of endocannabinoids on pentilenetetrazole induced seizures in mice
- Tez No: 164472
- Danışmanlar: PROF. DR. SEMİH KESKİL
- Tez Türü: Tıpta Uzmanlık
- Konular: Nöroşirürji, Neurosurgery
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2005
- Dil: Türkçe
- Üniversite: Kırıkkale Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Nöroşirürji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 41
Özet
ABSTRACT Yücel Engin, Effects of Endocannabinoids on Pentilenetetrazole induced seizures in mice, University of Kırıkkale, Faculty of Medicine, Department of Neurosurgery, Thesis, Kırıkkale 2005. Pentylenetetrazole (PTZ) is an agent widely used in the assessment of putative anticonvulsant drugs and is suggested to induce repetitive firing of nerve fibers and shorten the refractory period. This agent has been shown to impair GABAA-receptor-mediated inhibitory post-synaptic potentials and conductance. Anandamid is synthesized in neurons, excreted by depolarization and inactivated very quickly. Neonatal rat brain produces significantly more anandamid and its precursors after injury than controls. It has been shown that anandamid protected cerebral neurons of rats in in vitro ischemia. In neuronal disorders such as epilepsy, high levels of endocannabinoid anandamid were observed. Hydrolysis of endocannabinoid anandamid is mediated by CB1 receptors, located in the CNS. Ethanol is a psychoactive and addictive substance with diverse effects in the central nervous system (CNS). After acute application ethanol has an anticonvulsive effect as repeated administrations of high doses with longer withdrawal periods leads to proconvulsant actions, possibly mediated by neuroadaptive changes in NMDA and/or GABAa receptor related mechanisms. In this study we planned to study the anticonvulsant effects of endocannabinoids on PTZ induced seizures. In order to show that Swiss Albino mice were used. The mice were divided into four groups as control, anandamide, WIN- 55.212-2 and ethanol groups. Our findings show that, after i.p. administration of anandamide and ethanol followed by PTZ, latency period was significantly higher than the control, but there was no significant difference between seizure durations. Although latency period of the anandamide group was higher than ethanol group there was no statistical significance. Mortality rates of the ethanol (0%), anandamide (0%) and WIN 55.212- 2 (20%)groups were significantly lower than the control (46%) (p
Özet (Çeviri)
ABSTRACT Yücel Engin, Effects of Endocannabinoids on Pentilenetetrazole induced seizures in mice, University of Kırıkkale, Faculty of Medicine, Department of Neurosurgery, Thesis, Kırıkkale 2005. Pentylenetetrazole (PTZ) is an agent widely used in the assessment of putative anticonvulsant drugs and is suggested to induce repetitive firing of nerve fibers and shorten the refractory period. This agent has been shown to impair GABAA-receptor-mediated inhibitory post-synaptic potentials and conductance. Anandamid is synthesized in neurons, excreted by depolarization and inactivated very quickly. Neonatal rat brain produces significantly more anandamid and its precursors after injury than controls. It has been shown that anandamid protected cerebral neurons of rats in in vitro ischemia. In neuronal disorders such as epilepsy, high levels of endocannabinoid anandamid were observed. Hydrolysis of endocannabinoid anandamid is mediated by CB1 receptors, located in the CNS. Ethanol is a psychoactive and addictive substance with diverse effects in the central nervous system (CNS). After acute application ethanol has an anticonvulsive effect as repeated administrations of high doses with longer withdrawal periods leads to proconvulsant actions, possibly mediated by neuroadaptive changes in NMDA and/or GABAa receptor related mechanisms. In this study we planned to study the anticonvulsant effects of endocannabinoids on PTZ induced seizures. In order to show that Swiss Albino mice were used. The mice were divided into four groups as control, anandamide, WIN- 55.212-2 and ethanol groups. Our findings show that, after i.p. administration of anandamide and ethanol followed by PTZ, latency period was significantly higher than the control, but there was no significant difference between seizure durations. Although latency period of the anandamide group was higher than ethanol group there was no statistical significance. Mortality rates of the ethanol (0%), anandamide (0%) and WIN 55.212- 2 (20%)groups were significantly lower than the control (46%) (p
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