Geri Dön

Hidrokinon'un (HK) gelişim toksisitesinin döllenmiş tavuk embriyosunda analiz ve değerlendirilmesi

Başlık çevirisi mevcut değil.

  1. Tez No: 22358
  2. Yazar: MEBRURE ÖZCAN
  3. Danışmanlar: DOÇ. DR. SEMA BURGAZ
  4. Tez Türü: Yüksek Lisans
  5. Konular: Eczacılık ve Farmakoloji, Pharmacy and Pharmacology
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 1992
  8. Dil: Türkçe
  9. Üniversite: Gazi Üniversitesi
  10. Enstitü: Sağlık Bilimleri Enstitüsü
  11. Ana Bilim Dalı: Farmasötik Toksikoloji Ana Bilim Dalı
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: 132

Özet

Özet yok.

Özet (Çeviri)

- 114 - VII. SUMMARY Hydroquinone (HQ) is used as a reductant in photographic developing and in industrial ink production. It is one of the products of the oxidative benzene metabolism. HQ also finds application in cosmetics production. There is very limited information available on the developmental toxic effects of HQ. The effects of HQ were studied on the chick embryos on 3. and 4. days of incubation. HQ was dissolved in physiological saline and injected into the air sacs of the eggs at doses ranging from 0.0625 to 40 ug per egg. The controls received an equal amount of saline only (0.05 ml per egg). On the 15th day of incubation, the live embryos including controls were removed from the eggs and examined for gross malformations. In all, 585 eggs were utilized for this study. The LDso values for HQ on the third and forth day of deve'opment were 3.59 and 15.63 ug per egg respectively. HQ has produced gross malformations such as body hemorrhage, curled claws, everted viscera, defective beak, exencephaly and monophtalmia in developing chick embryos at dosages ranging from 20 to 0.0625 ug per egg in both groups. The various types of malformations and their incidences in both the groups were higher in comparision with the controls, but it is not significant statistically (p>0.05). Following the 3. and 4. days of incubation, the overall incidence of abnormal embryos was 24,7% and 22.22%, respectively. The results of this study indicate that HQ is embryotoxic at higher doses and that teratogenic potential of HQ is unremarkable.

Benzer Tezler

  1. Hidrokinon molekülünün katkılı ve katkısız fullerenlerle etkileşiminin kuantum mekaniksel yöntemlerle incelenmesi

    Investigation of interaction of hydroquinone molecule with pristine and doped fullerenes by quantum mechanical methods

    ORKUN ERGÜRHAN

    Yüksek Lisans

    Türkçe

    Türkçe

    2019

    Fizik ve Fizik MühendisliğiEge Üniversitesi

    Fizik Ana Bilim Dalı

    DOÇ. DR. CEMAL PARLAK

  2. 7,12-dimetil benz(a) antrasen verilen ratların lipit bileşenleri üzerine trolox ve hidrokinon'un etkisi

    Effect of trolox and hydroquinone on lipid species of rats given 7,12-dimethylbenz(a) antracene

    MUSTAFA GÜNDÜZ

    Yüksek Lisans

    Türkçe

    Türkçe

    2002

    KimyaFırat Üniversitesi

    Kimya Ana Bilim Dalı

    DOÇ.DR. SAİT ÇELİK

  3. S-triazin kullanılarak çok dişli schiff bazlarının sentezi, karakterizasyonu ve bazı geçiş metali komplekslerinin incelenmesi

    The synthesis, characterization and investigation of some transition metal complexes of multi-threaded schiff bases using s-triazine

    ERDEM BÜYÜKASLAN

    Yüksek Lisans

    Türkçe

    Türkçe

    2023

    KimyaKarabük Üniversitesi

    Kimya Ana Bilim Dalı

    PROF. DR. ŞABAN UYSAL

  4. Naftoksi veya kinolinoksi grupları içeren yeni hegzadeka sübstitüe ftalosiyaninler

    Novel hexadeca substituted phthalocyanines containing naphthoxy or quinolinoxy groups

    ÖZGE KURT

    Doktora

    Türkçe

    Türkçe

    2015

    Kimyaİstanbul Teknik Üniversitesi

    Kimya Ana Bilim Dalı

    PROF. DR. MAKBULE KOÇAK