Synthesis of glutamate receptor agonists and antagonists
Başlık çevirisi mevcut değil.
- Tez No: 400526
- Danışmanlar: PROF. DR. DOUGLAS W. YOUNG
- Tez Türü: Yüksek Lisans
- Konular: Fizik ve Fizik Mühendisliği, Kimya, Çevre Mühendisliği, Physics and Physics Engineering, Chemistry, Environmental Engineering
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1996
- Dil: İngilizce
- Üniversite: University of Sussex
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 59
Özet
.
Özet (Çeviri)
L-Glutamate is an excitatory amino acid and plays an important role in many processes in the brain including memory and learning. It is also a primary contributor to diseases such as stroke and epilepsy. Glutamate receptor agonists and antagonists have gained significance due to their use in treating diseases. Our aim was to develop a new method for the synthesis of glutamate agonists and antagonists via ring transformation reactions, starting from readily available (2S)-pyroglutamic acid. The first chapter reviews the existing literature on the classification of glutamate receptors, their involvement in the brain diseases and the previous work in the same field. /w-Butyl a-[(2S)-2-ethyloxycarbonyl-5-pyrrolidinylidene]cyanoacetate has been successfully synthesised following J. M. Berry's work from (2S)-pyroglutamic acid. The reaction of tert-butyl oc-[(2S)-2-ethyloxycarbonyl-5-pyrroIidinylidene]cyanoacetate with hydrazine has yielded ten-butyl a-[(2S)-2-hydrazinocarbonyl-5-pyrrolidinylidene]cyanoacetate rather than alkylpyrazoles which were our target compounds. These are the subjects of chapter 2. The products were identified using 'H-NMR, 13C-NMR and mass spectra.
Benzer Tezler
- Computational approaches to assess the binding properties of ligands: The case of the nmda receptor
Ligand bağlanma özelliklerinin değerlendirilmesinde hesapsal yaklaşımlar: Nmda reseptörü olgusu
ZEYNEP PINAR HAŞLAK
- Bağımlılıkta gelişen glutamat eksitotoksisitesine bağlı nörodejenerasyonun engellenmesi
Prevention of glutamate induced neurodegeneration in the course of addiction
CANER GEYİK
Doktora
Türkçe
2020
BiyokimyaEge ÜniversitesiMadde Bağımlılığı Ana Bilim Dalı
PROF. DR. DİLEK ODACI DEMİRKOL
- Glukokortikoidlerin neden olduğu hipokampal hasarda nitrerjik ve glutamaterjik sistemlerin olası rollerinin sıçanlarda incelenmesi
Searching possible role of nitrergic and glutamergic systems in hippocampal injury caused by glucocorticoids in rats
EMRE KIZILTAN
Doktora
Türkçe
2004
Eczacılık ve Farmakolojiİstanbul ÜniversitesiFarmakoloji Ana Bilim Dalı
PROF.DR. LÜTFİYE EROĞLU
- Kinürenik asit ve kinaldik asit'in insan karaciğer kanseri (HepG2) hücre hattında in vitro antitümöral etkilerinin araştırılması
Investigation of the in vitro antitumoral effects of kynurenic acid and quinaldic acid in hepatocellular carcinoma (HepG2) cell li̇ne
PINAR ATALAY DÜNDAR
Doktora
Türkçe
2019
Tıbbi BiyolojiErciyes ÜniversitesiTıbbi Biyoloji Ana Bilim Dalı
PROF. DR. NEFİSE NALAN İMAMOĞLU ŞİRVANLI
