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Sex-associated DNA markers in the Atlantic halibut (Hippoglossus hippoglossus)

Başlık çevirisi mevcut değil.

  1. Tez No: 403280
  2. Yazar: MÜNEVVER ORAL
  3. Danışmanlar: Dr. ANDREW DAVIE
  4. Tez Türü: Yüksek Lisans
  5. Konular: Balıkçılık Teknolojisi, Fisheries Technology
  6. Anahtar Kelimeler: Allele specific PCR, SNPs, sex determination, RAD tags, Hippoglossus
  7. Yıl: 2012
  8. Dil: İngilizce
  9. Üniversite: Unıversıty Of Stırlıng
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

Özet

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Özet (Çeviri)

Atlantic halibut (Hippoglossus hippoglossus) is one of the candidates for cold water marine aquaculture. Females grow faster and mature later than males which makes it desirable to have monosex female production in commercial scale. This study focuses on the development of sex-associated markers that can be used to assist development of monosex female production by decreasing the laborious process of progeny testing. Sexed individuals from former studies which had balanced sex ratios (50% and 47.5% females respectively) were used to generate Restriction Associated DNA RAD tags from next generation sequencing technology. Restriction Associated DNA (RAD) tags were used to generate five putative Y contigs and eleven allele specific SNP assays from 67,466 identified markers. Sex association was investigated by analysing seven SNP loci using allele-specific PCR. Two of these loci (Hhi58665 and Hhi41238) predicted the phenotypic sex of unrelated offspring with 93% accuracy within the entire dataset (p < 10-15) whereas putative Y markers failed. These results represent an example of the potential of next generation sequencing systems with high throughput to analyse sex in aquaculture species. Understanding sex determination mechanism and developing sex associated markers will give a boost to halibut industry, shortening the time for monosex female production to come to market and establish stable commercial production, decreasing the costs of farming.

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