Clinical use of urinary gonadotropin determination in children and adolescents
Başlık çevirisi mevcut değil.
- Tez No: 509108
- Danışmanlar: Prof. RAIMO VOUTILAINEN, Prof. ULF-HAKAN STENMAN
- Tez Türü: Doktora
- Konular: Eczacılık ve Farmakoloji, Çocuk Sağlığı ve Hastalıkları, Pharmacy and Pharmacology, Child Health and Diseases
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2015
- Dil: İngilizce
- Üniversite: Unıversıty Of Helsınkı
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
Özet yok.
Özet (Çeviri)
Th is study was undertaken to assess the feasibility of non-invasive sampling and assay of urinary gonadotropins for clinical evaluation of pubertal development. In the fi rst study, the concentrations of LH and FSH in concurrent serum and fi rst-morning-voided (FMV) urine samples of 820 children (486 boys and 334 girls, age 0-17 years) were determined with time-resolved immunofl uorometric assay (IFMA). Th e detection limit of IFMA was 0.018 IU/L for FSH, 0.015 IU/L for LH and 0.012 IU/L for LHspec. It was possible to measure the low prepubertal LH and FSH concentrations reliably in these samples due to the high sensitivity and low detection limits of IFMA. Th e correlation between serum and urinary gonadotropin values was high (r=0.751; p<0.001 for FSH and r=0.720; p<0.001 for LH), and the urinary and serum concentrations were close to each other. Correcting urinary gonadotropin concentrations on the basis of urinary density or creatinine did not improve the correlation. Age-related changes in urinary LH and FSH (U-LH and U-FSH) were examined. Th e concentrations of U-LH and U-FSH decreased from birth until the child was a few months old, aft er which the upper range of the U-LH levels of girls remained stable at below 0.5 IU/L until age 9 years and of boys below 1.0 IU/L until age 11 years. Th e upper range of the U-FSH levels of girls remained below 3.0 IU/L until age 10 years and of boys below the same concentration until age 12 years. Th e median U-LH concentration during the prepubertal period was about 0.06 for girls and 0.07 for boys. For the boys, this fi gure rose 10-fold by age 11, 40-fold by age 12 and 50-fold by age 13-14. Th e overall increase in the median U-LH concentrations was 75-fold from 5 to 15 years and 35-fold from Tanner stage G1 to G5. Th e corresponding fi gures for girls were 30-fold by age 11, 70-fold by age 12 and 90-fold by age 14; the overall increase in median U-LH concentrations was 90-fold from 5 to 15 years and 40-fold from Tanner stage B1 to B5 times. Th ese fi nding indicate that the U-LH concentrations of FMV samples obtained from clinically prepubertal children refl ect pubertal levels. Th e age-related changes in U-FSH concentrations were similar for boys and girls; the only diff erence was that the levels were generally higher for girls, in particular between ages 2–8 years. U-FSH reached a 5-fold level compared to prepubertal levels by the end of the puberty in both sexes. FMV U-LH, U-FSH and their ratios correlated well with the corresponding basal and GnRH-stimulated serum concentrations (P<0.001). Receiver operating characteristic (ROC) curve analyses of urinary and serum LH and FSH concentrations showed that FMV U-LH and U-LH/ U-FSH performed equally well as the GnRH test for diff erentiating early puberty (Tanner 2) from prepuberty (Tanner 1) [area under the curve (AUC) 0.768-0.890 vs. 0.712-0.858]. FMV U-LH and U-LH/U-FSH performed equally well as basal S-LH for predicting a pubertal GnRH test result (AUCs 0.90–0.93). Among the tests studied, only FMV U-LH diff erentiated the transitions from Tanner stage 1 to 2 and Tanner stage 2 to 3 (p<0.001 for boys and p=0.003 for girls). Again, this corroborates that FMV U-LH is the most reliable tool for evaluation of pubertal development. Th erefore, FMV urinary LH determinations, which are non-invasive and, at most, minimally stressful for the child patient, can be used for preliminary diagnostic evaluation of pubertal development. It reduces the need for S-LH determinations and the GnRH stimulation tests, both invasive procedures.
Benzer Tezler
- Açıklanamayan infertilitesi olan hastalarda klomifen sitrat, klomifen sitrat + FSH ve FSH'nın intrauterin inseminasyonda kullanımının gebelik sonuçlarına etkisinin karşılaştırılması
Comparison of the effects of the use of clomiphene citrate, clomiphene citrate + FSH and FSH in intrauterin insemination on pregnancy outcomes in patients with unexplained infertility
REYHAN AYAZ
Tıpta Uzmanlık
Türkçe
2011
Kadın Hastalıkları ve DoğumSağlık BakanlığıKadın Hastalıkları ve Doğum Ana Bilim Dalı
DR. MEHMET ULUDOĞAN
- İn vitro fertilizasyon hastalarında rekombinant ve ürinerluteinizan hormon kullanımının karşılaştırmalı sonuçları
Comparative outcomes of recombinant and urinary LH use in IVF patients
İBRAHİM HALİL MEHMET AKIN
Tıpta Uzmanlık
Türkçe
2026
Kadın Hastalıkları ve DoğumHarran ÜniversitesiKadın Hastalıkları ve Doğum Ana Bilim Dalı
PROF. DR. MUHAMMET ERDAL SAK
- Over kanserinde kullanılmak üzere lhrh reseptör hedefli peg-plga-pga triblok sisplatin içeren polimerik misellerin hazırlanması ve oral yolla kullanım olanaklarının in vitro/ ex vivo / in vivo araştırmaları
Preparation of lhrh receptor targeted cisplatin containing peg-plga-pga triblock polymeric micelles for use in ovarian cancer and investigation the possibilities in oral administration with in vitro/ex vivo/in vivo studies
İRFAN AKARTAŞ
Doktora
Türkçe
2017
Eczacılık ve FarmakolojiEge ÜniversitesiFarmasötik Teknoloji Ana Bilim Dalı
PROF. DR. HATİCE YEŞİM KARASULU
- Mesane tümörlerinde tümör belirleyicisi olarak karsinoembriyojenik antijen, karbonhidrat antijen 19-9, beta human koryonik gonadotropin ve transferrinin kan ve idrar düzeyleri
Blood and urine carcinoembrionic antigen, carbonhydrate antigen 19-9, beta-human chorionic gonadotropin and transferrin levels as specific markers of bladder tumors
YILMAZ AKSOY
- İdrar elektrolitlerinin klinik pratikte kullanımının araştırılması
Investigation of the use of urinary electrolytes in clinical practice
GAMZE KESKİ
Tıpta Uzmanlık
Türkçe
2025
İç HastalıklarıSağlık Bilimleri Üniversitesiİç Hastalıkları Ana Bilim Dalı
PROF. DR. SERDAR KAHVECİOĞLU