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The effect of experimental variables on the formulation ofophthalmic inserts, fabricated by solvent casting method

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  1. Tez No: 707868
  2. Yazar: İLAYDA ÇETİN
  3. Danışmanlar: DR. ALİ AL-KINANI, PROF. RAİD ALANY
  4. Tez Türü: Yüksek Lisans
  5. Konular: Farmasötik Toksikoloji, Kimya Mühendisliği, Kimya, Pharmaceutical Toxicology, Chemical Engineering, Chemistry
  6. Anahtar Kelimeler: Belirtilmemiş.
  7. Yıl: 2017
  8. Dil: İngilizce
  9. Üniversite: Kıngston Unıversıty
  10. Enstitü: Yurtdışı Enstitü
  11. Ana Bilim Dalı: Belirtilmemiş.
  12. Bilim Dalı: Belirtilmemiş.
  13. Sayfa Sayısı: Belirtilmemiş.

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Özet (Çeviri)

Background and Aim: Ocular drug delivery is a very challenging process due to the complex and selective anatomy of the eye. Precorneal loss factors such as solution drainage, induced lacrimation, tear film, tear turn over, blinking, conjunctival and non-productive absorptions, and also layered structure of the cornea are the main restrictions of the ocular drug absorption. Conventional ocular drug delivery systems are not good enough to overcome the challenges. Ocular inserts are one of the novel therapeutics with many advantages including controlled sustained drug release and increased retention time resulting in better bioavailability, reduced eye irritation and less administration frequency resulting in better patient compliance. The aim of the study was to examine the effect of the polymer and the plasticiser concentration on the formulation of ocular inserts to produce better featured inserts. Methods: Experimental grid was generated by design of experiment (DoE), Minitab 17 software. Ocular inserts containing sodium alginate (ALG), polyvinyl alcohol (PVA), k-Carrageenan (k-Carr) and glycerol (GLY) were produced by solvent casting method with varying polymer and plasticiser concentrations. Casted inserts were characterised for weight and thickness variation, pH, percentage moisture uptake, contact angle, folding endurance, tensile strength, SEM, mucoadhesion and BCOP tests. The obtained data were fed into DoE to analyse the effect of each variable on the responses. Results: The results showed that increase in PVA concentration and GLY amount resulted in more elastic and hydrophilic ocular films whereas increase in ALG concentration produced more hydrophobic, tough and rigid films with higher tensile strength. Mucoadhesion, on the other hand, was found to be directly proportional with ALG concentration and GLY amount whereas the inverse relation was present with PVA concentration. Acquired data demonstrated that k-Carr concentration had minor effect on responses compared to other excipients, but it was observed that it facilitated the moisture uptake and increased the contact angle of the films. Conclusion: The study demonstrated that the design of experiment is a very crucial application to optimise the formulation of the ocular inserts. Ideal inserts with better bioavailability could be produced by manipulating the concentrations of the polymers and the plasticiser.

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