The effects of a diet reflecting the intakes of the poorest socioeconomic group in Scotland on themetabolism of the mother and her offspring using thelaboratory rat as a model
Başlık çevirisi mevcut değil.
- Tez No: 760305
- Danışmanlar: DR. WİLLİAM D. REES
- Tez Türü: Doktora
- Konular: Beslenme ve Diyetetik, Nutrition and Dietetics
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2021
- Dil: İngilizce
- Üniversite: University of Aberdeen
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 295
Özet
Özet yok.
Özet (Çeviri)
The Scottish diet contains an excess of energy, saturated fat, and salt, while at the same time is poor in several key micronutrients. An animal model has been used to test the hypothesis that this imbalanced diet programs offspring metabolism. Female rats have been fed a diet (SIMD) formulated to reflect the diet of the poorest pregnant women and compared with animals fed a diet (SACN) formulated to incorporate the current UK recommendations. For comparison a third groups of animals were fed the widely used AIN-93G diet. Animals fed the SACN diet had more body fat compared to the AIN-93G group prior to mating. Fetal weights were comparable in all three groups, however postnatal lean tissue growth in the SIMD and SACN offspring was reduced. This was associated with lower dietary protein content and quality. There were extensive changes in the fatty acid profiles of maternal tissues and animals fed the SIMD diet accumulated triglyceride in the liver. LCPUFA, notably arachidonic acid was lower in the fetal brain, however by weaning, the profiles were similar, suggesting fetal brain development is susceptible to an imbalanced maternal diet. To test the long-term consequences, offspring were maintained on stock diet up to 37 weeks of age. At 4-weeks of age, pups from dams fed SACN diet had a greater proportion of body fat however this was transient and by 10 weeks of age the proportion of body fat was similar in all three groups. The maternal diet did not create persistent changes in food intake or differences in glucose homeostasis (assessed by HOMA or insulin tolerance test) in the adult offspring. In conclusion, maternal metabolism and the mobilisation of maternal reserves serves to protect the developing offspring.
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