An investigation of the humoral immune response to mRNA COVID-19 vaccination with two doses versus three doses in Iraq/Baghdad
Irak/Bağdat'ta mRNA COVID-19 aşılamasında ikinci doza karşı üçüncü dozun humoral yanıtının araştırılması
- Tez No: 790856
- Danışmanlar: PROF. DR. Ülkünihan YAZGAN TAVŞANOĞLU, PROF. DR. AHMED SAHİB ABDULAMİR ALABDAWI
- Tez Türü: Yüksek Lisans
- Konular: Biyoloji, Biology
- Anahtar Kelimeler: PCR, IgG, Covid-19, mRNA vaccine, Humoral immune response, Aşılar, COVID 19, Irak, Irak-Bağdat, SARS virüsü, Vaccines, COVID 19, Iraq, Iraq-Baghdad, SARS virus
- Yıl: 2022
- Dil: İngilizce
- Üniversite: Çankırı Karatekin Üniversitesi
- Enstitü: Fen Bilimleri Enstitüsü
- Ana Bilim Dalı: Biyoloji Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
As a result of the SARS-CoV-2 epidemic, several vaccines against COVID-19 have been produced around the world. The BNT162b2 mRNA vaccine was the first approved vaccine because of its effectiveness in inducing a humoral immune response immediately after the second dose. However, it was determined that there was a decrease in the antibody level over time. The aim of this study is to compare the efficacy of the third dose of Covid-19 mRNA vaccines with the pre-mRNA-based Pfizer vaccine by detecting the level of post-vaccination serum anti-SARS-CoV-2 antibodies. The samples were collected form 120 individuals and after the second dose, the infected Covid-19 individuals were not included in the analysis has been excluded. According to the results obtained, no statistically significant changes were detected in HCT, Hb, Lymphatic %, Neutrophils %, Basophil %, Eosinophil % and LDH. However, WBC, Monocyte % and Platelets showed statistically significant changes (p< 0.05). In addition, Neutralizing antibody (Nab), hs-CRP, IgG and IgM showed statistically significant changes (p< 0.00). As a result, according to the data obtained from 120 people in Baghdad, it was determined that the third dose of BNT162b2 vaccine had positive effects on the humoral immune response. 2022, 52 pages
Özet (Çeviri)
As a result of the SARS-CoV-2 epidemic, several vaccines against COVID-19 have been produced around the world. The BNT162b2 mRNA vaccine was the first approved vaccine because of its effectiveness in inducing a humoral immune response immediately after the second dose. However, it was determined that there was a decrease in the antibody level over time. The aim of this study is to compare the efficacy of the third dose of Covid-19 mRNA vaccines with the pre-mRNA-based Pfizer vaccine by detecting the level of post-vaccination serum anti-SARS-CoV-2 antibodies. The samples were collected form 120 individuals and after the second dose, the infected Covid-19 individuals were not included in the analysis has been excluded. According to the results obtained, no statistically significant changes were detected in HCT, Hb, Lymphatic %, Neutrophils %, Basophil %, Eosinophil % and LDH. However, WBC, Monocyte % and Platelets showed statistically significant changes (p< 0.05). In addition, Neutralizing antibody (Nab), hs-CRP, IgG and IgM showed statistically significant changes (p< 0.00). As a result, according to the data obtained from 120 people in Baghdad, it was determined that the third dose of BNT162b2 vaccine had positive effects on the humoral immune response.
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