The relationship between sperm midpiece details and DNA fragmentation in human sperm
Başlık çevirisi mevcut değil.
- Tez No: 903605
- Danışmanlar: PROF. DR. KAAN AYDOS
- Tez Türü: Doktora
- Konular: Kadın Hastalıkları ve Doğum, Üroloji, Obstetrics and Gynecology, Urology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2024
- Dil: İngilizce
- Üniversite: Ankara Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Kadın Hastalıkları ve Doğum Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 52
Özet
Our study aimed to investigate the relationship between sperm morphology and sperm DNA damage in men with teratozoospermia issues. Between December 2022 and June 2024, 239 infertile men aged 18-45 were prospectively enrolled. Semen samples from each participant were thoroughly analyzed, and defects in the head, neck-middle piece, and tail regions were recorded based on 50 randomly selected spermatozoa per patient, totaling 11,950 spermatozoa. Data comparing abnormal versus normal morphology groups were used to calculate a cutoff value for DNA fragmentation index (DFI), which was then applied to compare patient data. Subsequently, correlations between midpiece measurements and DFI were assessed. A cutoff value of 19.50 was determined for sperm DFI. The ratio of normal neck and midpiece in DFI
Özet (Çeviri)
Our study aimed to investigate the relationship between sperm morphology and sperm DNA damage in men with teratozoospermia issues. Between December 2022 and June 2024, 239 infertile men aged 18-45 were prospectively enrolled. Semen samples from each participant were thoroughly analyzed, and defects in the head, neck-middle piece, and tail regions were recorded based on 50 randomly selected spermatozoa per patient, totaling 11,950 spermatozoa. Data comparing abnormal versus normal morphology groups were used to calculate a cutoff value for DNA fragmentation index (DFI), which was then applied to compare patient data. Subsequently, correlations between midpiece measurements and DFI were assessed. A cutoff value of 19.50 was determined for sperm DFI. The ratio of normal neck and midpiece in DFI
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