Perinatal asfiksi tanılı hastalarda NRF2, tau ve oksidatif durum
NRF2 TAU and oxidative status in patients diagnosed with perinatal asphyxia
- Tez No: 924830
- Danışmanlar: DOÇ. DR. HÜSEYİN GÜMÜŞ
- Tez Türü: Tıpta Uzmanlık
- Konular: Çocuk Sağlığı ve Hastalıkları, Child Health and Diseases
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2025
- Dil: Türkçe
- Üniversite: Harran Üniversitesi
- Enstitü: Tıp Fakültesi
- Ana Bilim Dalı: Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 77
Özet
Aim: To investigate the change in NRF2 (Nuclear Factor Erythroid-2), which plays a critical role in protecting against oxidative stress in cases diagnosed with perinatal asphyxia; The aim is to investigate the relationship of parts of the NRF2 change with the TAU protein, which is an objective indicator of injury. Materials and Methods: This study was conducted in the Tertiary Neonatal Intensive Care Unit (NICU) with a total of 80 cases, 50 patients and 30 control groups. To investigate NRF2, TAS-TOS (Total Antioxidant Level-Total Oxidative Level) and TAU levels, 2 cc blood samples were taken from the cases within the first 6 hours after birth, centrifuged and stored at -80°C until the study. NRF2, TAS-TOS, TAU levels were studied using the ELlSA (Enzyme-Linked ImmunoSorbent Assay) kit. The data obtained was analyzed using SPSS 26 (Statistical Package for the Social Sciences) program. Results: To work; A total of 80 cases, 50 patients and 30 control groups, were included. 62.5% of the cases participating in the study were in the patient group and 37.5% were in the control group. There was no significant difference between the groups in terms of gender (p>0.05). There was no significant difference between the groups in terms of week of birth (p>0.05). There was no significant difference between the groups in terms of birth weight (p>0.05). TOS, OSI and TAU levels of the patient group were significantly higher than those of the control group (p
Özet (Çeviri)
Aim: To investigate the change in NRF2 (Nuclear Factor Erythroid-2), which plays a critical role in protecting against oxidative stress in cases diagnosed with perinatal asphyxia; The aim is to investigate the relationship of parts of the NRF2 change with the TAU protein, which is an objective indicator of injury. Materials and Methods: This study was conducted in the Tertiary Neonatal Intensive Care Unit (NICU) with a total of 80 cases, 50 patients and 30 control groups. To investigate NRF2, TAS-TOS (Total Antioxidant Level-Total Oxidative Level) and TAU levels, 2 cc blood samples were taken from the cases within the first 6 hours after birth, centrifuged and stored at -80°C until the study. NRF2, TAS-TOS, TAU levels were studied using the ELlSA (Enzyme-Linked ImmunoSorbent Assay) kit. The data obtained was analyzed using SPSS 26 (Statistical Package for the Social Sciences) program. Results: To work; A total of 80 cases, 50 patients and 30 control groups, were included. 62.5% of the cases participating in the study were in the patient group and 37.5% were in the control group. There was no significant difference between the groups in terms of gender (p>0.05). There was no significant difference between the groups in terms of week of birth (p>0.05). There was no significant difference between the groups in terms of birth weight (p>0.05). TOS, OSI and TAU levels of the patient group were significantly higher than those of the control group (p
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