Bone and cartilage metabolism in canine arthropathies
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- Tez No: 400601
- Danışmanlar: PROF. DR. STUART CARTER, PROF. DR. DAVID BENNETT
- Tez Türü: Doktora
- Konular: Veteriner Hekimliği, Veterinary Medicine
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 1995
- Dil: İngilizce
- Üniversite: Unıversıty Of Lıverpool
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
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Özet (Çeviri)
Studies of cartilage, synovial membrane and bone biochemistry have been important in studying the mechanisms of human osteoarthritis (OA) and rheumatoid arthritis (RA) and the search for a marker of joint damage resulting from OA or RA has become an important issue for many researchers in rheumatology. Most of the potential markers have been of inflammatory processes, cartilage destruction or bone erosion. Both OA and RA are clinically important diseases of the dog and there is no available data on changes in connective tissue molecules in these occurring diseases. This study investigated the relationship between markers of bone and cartilage turnover detected in sera and synovial fluids in naturally occurring canine joint diseases. Cartilage matrix molecules; glycosaminoglycans, KS, C 4-S, antibodies against to collagen I and II and pyridinoline were considered as potential markers of cartilage metabolism. Keratan sulphate, C 4-S and antibodies to collagen I and II were measured by ELISA. Dimethylmethylene blue assay was used for the estimation of total GAG. Pyridinoline was measured by high performance liquid chromatography (HPLC). Anti-collagen type II levels in synovial fluids and sera of dogs with OA and CCL were significantly higher than in normal dogs. GAG levels in synovial fluids of dogs with OA and RA were significantly higher than those in synovial fluids of normal dogs (p<0.002). Synovial fluid KS levels of RA dogs (p<0.001) and serum KS levels of dogs (p<0.05) were significantly increased compared to normal dogs. Whilst increased levels of keratan sulphate and GAG were found in dogs with OA, they were not considered useful diagnostically. Hyaluronan (HA), a high molecular weight polysaccharide, is widely distributed in connective tissues. Hyaluronan is considered to be a marker of synovial membrane metabolism. Levels of sera and synovial fluid HA were determined by ELISA. HA levels in synovial fluids (SF) of OA (p<0.001) and CCL (p<0.05) dogs were significantly lower than in normal dogs. HA levels in the sera of dogs with OA (p<0.001), CCL (p<0.05) and liver disease (p<0.001) were significantly higher than in control dogs. Osteocalcin (OC), antibody to collagen type I, alkaline phophatase and deoxypyridinoline were considered as potential markers of bone metabolism. Osteocalcin was measured by radioimmunoassay. Significantly higher serum OC, compared to normal dogs, was seen in dogs with OA (p<0.G05), RA (p<0.01) and CCL (p<0.02). Significantly reduced OC was found in RA synovial fluids. Linear regression analysis showed a correlation between KS and OC concentrations in OA synovial fluids and sera. There was also a correlation between serum and synovial fluid OC in OA. OC correlated with alkaline phosphatase (AP) in RA, but did not correlate with the incidence of erosive disease. The distribution of type VI collagen in normal and OA canine cartilage was determined by immunofluorescence and electron microscopic immunohistochemistry. In normal cartilage, type VI collagen was concentrated in the capsule immediately adjacent to the chondrocyte complex. However, in OA cartilage, it was found throughout the matrix but was greatly increased in areas surrounding the chondrocytes which were increased in number, particularly in the pericellular capsule and territorial matrix. The data demonstrate that none of the markers appear, singly, to be specific for diagnosis or prognostic application for osteoarthritis and rheumatoid arthritis, but, studies of cartilage, bone and synovial membrane markers of dogs with joint disease will give further insight into the pathogenesis of these diseases and may provide useful information for OA in other species, particularly man.
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