Etablierung und Optimierung der Kurzzeitkultivierung vonpatienten-abgeleiteten organotypischen Tumorsphären beimKopf-Hals-Karzinom
Başlık çevirisi mevcut değil.
- Tez No: 710500
- Danışmanlar: Belirtilmemiş.
- Tez Türü: Yüksek Lisans
- Konular: Biyoteknoloji, Biotechnology
- Anahtar Kelimeler: Belirtilmemiş.
- Yıl: 2019
- Dil: Almanca
- Üniversite: Technische Universität Berlin
- Enstitü: Yurtdışı Enstitü
- Ana Bilim Dalı: Belirtilmemiş.
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: 81
Özet
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Özet (Çeviri)
The cancer entity head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world with 60% 5-year survival rates for patients. Therefore, there is an urgent requirement for new diagnostic and therapeutic approaches to improve the early diagnosis and treatment of the disease. An important starting point for the therapy decision is personalized therapy. The goal is to extend useful and potentially less toxic treatment options for patients and to exclude non-effective therapies. Thus, the most effective curative procedures can be identified before the clinical- and drug therapy start. For the establishment of powerful and predictive tumor models the generation of three-dimensional (3D) culture systems based on patient-derived tumor cells is a significant achievement in precision medicine and regenerative therapies. 3D cell culture mimics the key features of the in vivo environment as well as cell-cell and cell-extracellular matrix interactions. This results in a suitable structural architecture and differentiated function of tumor cells and tumor stroma in vitro. The 3D model, which used in this work, is based on the tumor model that aims to generate patient-derived organotypic tumorspheres (PDOTS) using short-term culture. This pilot study involved the establishment of a method for the generation and maintenance of PDOTS using short-term culture of 6-7 days. For this purpose, patient-derived xenograft samples of the entity HNSCC, colorectal (CRC), sarcoma, ovarian and lymphoma as well as surgical patient samples with the entity HNSCC and Malignant Melanoma were processed and cultivated with different culture conditions. Accordingly, additional starting points during the processing of the tumor samples and cultivation must be optimized in order to obtain effective results and an accurate decision on the use of PDOTS for short-term culture of the entity HNSCC as a physiological model compared to long-term culture.
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