Böbrek transplantasyonu uygulanan hastalarda lipid peroksidasyonu ve antioksidanlar
Başlık çevirisi mevcut değil.
- Tez No: 80124
- Danışmanlar: PROF. DR. SERPİL NEBİOĞLU
- Tez Türü: Doktora
- Konular: Biyokimya, Biochemistry
- Anahtar Kelimeler: Cyclosporine, renal transplantation, rejection, LDL oxidation, and antioxidant, Antioksidanlar, Böbrek nakli, Lipid peroksidasyonu, Cyclosporine, renal transplantation, rejection, LDL oxidation, and antioxidant, Antioxidants, Kidney transplantation, Lipid peroxidation
- Yıl: 1998
- Dil: Türkçe
- Üniversite: Ankara Üniversitesi
- Enstitü: Sağlık Bilimleri Enstitüsü
- Ana Bilim Dalı: Biyokimya Ana Bilim Dalı
- Bilim Dalı: Belirtilmemiş.
- Sayfa Sayısı: Belirtilmemiş.
Özet
198 8. SUMMARY Lipid peroxidation and antioxidants in renal transplanted patients Transplantation is most effective method to save the life of renal diseased patient. Transplantation brings some life threatening complications, although it has vital importance. Many side effects have been known of immunusupressan drugs, especially cyclosporine A. The major complications are the lipid peroxidation, increased susceptibility of LDL oxidation and development of atherosclerosis. Rejection is one of the major complication of transplanted patients. There are several reasons of rejection. One of them is the hyperlipidemia of the recipient. The LDL oxidation has been found significantly higher among the CsA treated patients those used high level of CsA, as the susceptibility of LDL to oxidation has been studied. The prooxidan effect of CsA on plazma LDL in renal transplant patients may be an important risk factor of developing atherosclerosis. Atherosclerosis is the most important factor of mortality and morbidity of renal transplanted patients. Our aim in this study was to determine the lipid peroxidation, LDL oxidation, plasma and red blood cell glutation, glutation peroxidase, catalase, free carnitin, p- carotene, cc-tocopherol levels and biochemical parameters in transplant patients before transplantation and CsA treatment and every 15 days after, for 2 months and compare with same results of controls. In our study blood samples have been collected from 10 patient aged 30-39, before transplantation and CsA treatment and after, at 15 days intervals, for five times. Control group was containing 11 healthy volunteers aged 19-36. Trigliseride and total cholesterol levels have been increased and HDL concentration decreased significantly after transplantation in comparison before transplantation (p<0.05, p<0.0001, p<0.01) and control (p<0.0001, p<0.0001, p<0.001 respectively). A significant decrease has been determined at the plasma albumin and free carnitine levels according to that before transplantation (p<0.0001, p<0.001 respectively). Plasma uric acid concentration decreased after transplantation compare to the results before, however remain significantly higher than control levels (p<0.05). Plasma bilirubin values increased after CsA treatment (p<0.05). Plasma lipid peroxide levels diminished on 60.th days after transplantation (p<0.05) whereas LDL TBARS levels increased significantly compare to controls (p<0.0001) and199 remain high after CsA treatment (p<0.0001). The high levels of catalase activity decreased towards the control after transplantation (p<0.0001), while glutation peroxidase activity exerts no difference until the 30. day of CsA treatment. A decreased GPx activity was found 30 day after CsA treatment (p<0.001). A decrease in plasma glutation levels was obtained at the first 15 days after CsA treatment (p<0.0001) and a significant increase afterwards (p<0.05). The decrease in erythrocyte glutation levels was significant (p<0.0001) after CsA treatment compare to control and before transplantation. Plasma beta-carotene and E vitamin levels varied according to diet and season and the difference at beta-carotene levels were insignificant. A significantly decreased level of Vitamin E was observed 45 days after CsA treatment (p<0.01). As a result lipid parameters and susceptibility of LDL to oxidation have been increased and the level of anthiatherogenic substance HDL, and some antioxidants like albumin, karnitin, erithrosite end plasma glutation, glutation peroxidase decreased after transplantation and CsA treatment.
Özet (Çeviri)
198 8. SUMMARY Lipid peroxidation and antioxidants in renal transplanted patients Transplantation is most effective method to save the life of renal diseased patient. Transplantation brings some life threatening complications, although it has vital importance. Many side effects have been known of immunusupressan drugs, especially cyclosporine A. The major complications are the lipid peroxidation, increased susceptibility of LDL oxidation and development of atherosclerosis. Rejection is one of the major complication of transplanted patients. There are several reasons of rejection. One of them is the hyperlipidemia of the recipient. The LDL oxidation has been found significantly higher among the CsA treated patients those used high level of CsA, as the susceptibility of LDL to oxidation has been studied. The prooxidan effect of CsA on plazma LDL in renal transplant patients may be an important risk factor of developing atherosclerosis. Atherosclerosis is the most important factor of mortality and morbidity of renal transplanted patients. Our aim in this study was to determine the lipid peroxidation, LDL oxidation, plasma and red blood cell glutation, glutation peroxidase, catalase, free carnitin, p- carotene, cc-tocopherol levels and biochemical parameters in transplant patients before transplantation and CsA treatment and every 15 days after, for 2 months and compare with same results of controls. In our study blood samples have been collected from 10 patient aged 30-39, before transplantation and CsA treatment and after, at 15 days intervals, for five times. Control group was containing 11 healthy volunteers aged 19-36. Trigliseride and total cholesterol levels have been increased and HDL concentration decreased significantly after transplantation in comparison before transplantation (p<0.05, p<0.0001, p<0.01) and control (p<0.0001, p<0.0001, p<0.001 respectively). A significant decrease has been determined at the plasma albumin and free carnitine levels according to that before transplantation (p<0.0001, p<0.001 respectively). Plasma uric acid concentration decreased after transplantation compare to the results before, however remain significantly higher than control levels (p<0.05). Plasma bilirubin values increased after CsA treatment (p<0.05). Plasma lipid peroxide levels diminished on 60.th days after transplantation (p<0.05) whereas LDL TBARS levels increased significantly compare to controls (p<0.0001) and199 remain high after CsA treatment (p<0.0001). The high levels of catalase activity decreased towards the control after transplantation (p<0.0001), while glutation peroxidase activity exerts no difference until the 30. day of CsA treatment. A decreased GPx activity was found 30 day after CsA treatment (p<0.001). A decrease in plasma glutation levels was obtained at the first 15 days after CsA treatment (p<0.0001) and a significant increase afterwards (p<0.05). The decrease in erythrocyte glutation levels was significant (p<0.0001) after CsA treatment compare to control and before transplantation. Plasma beta-carotene and E vitamin levels varied according to diet and season and the difference at beta-carotene levels were insignificant. A significantly decreased level of Vitamin E was observed 45 days after CsA treatment (p<0.01). As a result lipid parameters and susceptibility of LDL to oxidation have been increased and the level of anthiatherogenic substance HDL, and some antioxidants like albumin, karnitin, erithrosite end plasma glutation, glutation peroxidase decreased after transplantation and CsA treatment.
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